Immunological characteristics of a patient with Belatacept-resistant acute rejection after face transplantation.

Belatacept has been introduced as a promising novel immunosuppressant to the field of transplantation, especially for patients suffering from adverse effects of conventional immunosuppression such as nephrotoxicity. Analysis of rejection episodes under costimulation-based regimen in kidney transplants suggested that high percentages of circulating CD4+ CD57+ PD1- cells pre-transplantation may be predictive markers for belatacept-resistant acute rejection (BRR) (1). We investigated this particular subset in one of our face transplant recipients who experienced complications of CNI-based immunosuppression.

Krezdorn N, Murakami N, Pomahac B, Riella LV.

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