He’s thriving nearly 4 months after receiving a gene-edited pig kidney at @mgh_transplant @MGHSurgery @MGHKidneys @harvardmed. “He was tired of just surviving. A pig kidney gave him a shot at living.” @CNN
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He was tired of just surviving. A pig kidney gave him a shot at living | CNN
Tim Andrews knew that he needed dialysis to manage his end-stage kidney disease, but over months of treatment, he ...
www.cnn.com
🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/5
🚨 Current therapies focus on T cells—but what if we’ve been overlooking a key player?
Our new study out today in @ScienceTM uncovers a natural "brake" in the innate immune system (Siglec) that is crucial to inhibit rejection. @mgh_transplant @MGHKidneys @ThiagoJBorges
News Release @MGBResearchNews @MGHSurgery here: https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/discovery-yields-insights-on-preventing-organ-transplant-rejection
Link to article here: https://www.science.org/doi/10.1126/scitranslmed.ads2694
Incredible work by @MGH_Transplant and Korkut Uygun’s team—successfully freezing a pig kidney and transplanting it later. A major step toward removing the time limits between organ donation and transplant. Game-changing breakthrough in the making!
This Kidney Was Frozen for 10 Days. Could Surgeons Transplant It?
Scientists developed a way to freeze a large mammal’s kidney, which could ease organ shortages in the future. Fi...
www.nytimes.com
Case presented @BWHKidney @MGHKidneys Grand Rounds. Nephrotic Syndrome in a 40-Year-Old Male.
A new-onset nephrotic syndrome with AKI, 15 g/day proteinuria, and no systemic symptoms
👨🏿🦱 African American male
📈 BMI 41
🧂 Hypertension
🎯 Let’s explore the differential approach
5/6🧪 Workup:
✅ Kidney Biopsy – critical to define the exact cause
✅ Labs:
• HIV, Hep B/C, Parvovirus
• PLA2R Abs
• Anti-Nephrin Abs (new research test for systemic or circulating FSGS)
• APOL1 genotyping if FSGS
✅ Cancer screening if membranous/MCD suspected
6/6 Biopsy showed diffuse podocytopathy and FSGS on light microscopy. The patient was homozygous for APOL1 high-risk variants and had positive anti-Nephrin Antibodies. Double hit... How would you treat this patient?
Honored to join the @TheAtlantic Health Summit in Boston on April 8 to speak about the first genetically-edited pig kidney transplant into a living recipient — a major milestone in transplantation.
Join us. https://live.theatlantic.com/en/AtlanticLIVE/HealthSummit2025/purchase.php?utm_source=speakers&utm_medium=crossplatform&utm_campaign=health25&utm_id=massgen
© 2024 Leo Riella
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