📢 New RCT in kidney transplant patients with chronic active AMR: IVIG (1g/kg x6 months) vs no IVIG (both w/ pulse steroids).
🧬 IVIG stabilized eGFR & improved molecular signatures—despite no DSA change.
đź’ˇ Option in pts where escalating immunosuppression is risky. @Kidney_Int
Link to the article here: https://pubmed.ncbi.nlm.nih.gov/40412552/
"Xenotransplantation — Long Awaited, Much Learned, Much More to Be Learned"
@NEJM Editorial by Editor-in-Chief, Sandy Feng @UCSFTransplant on the paper detailing the 1st xenokidney transplant with @amjtransplant AE @LVRiella @MGH_transplant as senior author. 10.1056/NEJMe2504399
He’s thriving nearly 4 months after receiving a gene-edited pig kidney at @mgh_transplant @MGHSurgery @MGHKidneys @harvardmed. “He was tired of just surviving. A pig kidney gave him a shot at living.” @CNN
đź”—
He was tired of just surviving. A pig kidney gave him a shot at living | CNN
Tim Andrews knew that he needed dialysis to manage his end-stage kidney disease, but over months of treatment, he ...
www.cnn.com
🚨 Our new study in @SciTranslMed identified the inhibitory receptor Siglec-E as a critical brake on dendritic cell activation and T cell–mediated transplant rejection. 1/5
🚨 Current therapies focus on T cells—but what if we’ve been overlooking a key player?
Our new study out today in @ScienceTM uncovers a natural "brake" in the innate immune system (Siglec) that is crucial to inhibit rejection. @mgh_transplant @MGHKidneys @ThiagoJBorges
News Release @MGBResearchNews @MGHSurgery here: https://www.massgeneralbrigham.org/en/about/newsroom/press-releases/discovery-yields-insights-on-preventing-organ-transplant-rejection
Link to article here: https://www.science.org/doi/10.1126/scitranslmed.ads2694
Incredible work by @MGH_Transplant and Korkut Uygun’s team—successfully freezing a pig kidney and transplanting it later. A major step toward removing the time limits between organ donation and transplant. Game-changing breakthrough in the making!
This Kidney Was Frozen for 10 Days. Could Surgeons Transplant It?
Scientists developed a way to freeze a large mammal’s kidney, which could ease organ shortages in the future. Fi...
www.nytimes.com
© 2024 Leo Riella
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