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🚨 Which exercise modality works best for patients with kidney disease?
🔬 Our latest study, published in @FrontPhysiol investigates the impact of various exercise modalities on chronic kidney disease.Check out our findings! 🧵👇 @mgh_transplant
@hugodlcorrea @ThiagoJborges
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🔬 Why does this matter?
Our findings reveal how specific exercise modalities improve key outcomes for CKD patients.
🧑⚕️ Tailored exercise plans can enhance quality of life, physical function, and mental health.
🤝 This study offers actionable insights for clinicians& patients
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✅ Takeaway: Combining strength + aerobic exercises provides the greatest overall benefits for CKD patients.
We hope this study empowers better exercise prescriptions to improve CKD outcomes! @MGHKidneys @BWHKidney
cc: @ThiagoRosa_17
🚨Publication🚨
Tacro to belatacept conversion in proteinuric kidney transplant recipients
-pilot singlearm interven. trial in KTRs w high-grade proteinuria
-Bela conversion➡️stable eGFR & proteinuria over yrs!
https://doi.org/10.3389/fimmu.2024.1491514
W @AlJurdi(cofirst),mentor💪@LVRiella,team👇
Great @mgh_transplant path rounds with Veronica 🧑⚕️ 38M with ESRD due to MPGN, s/p kidney transplant 1 year ago, presents with rising creatinine and 1g of proteinuria.
Biopsy: No rejection but segmental ↑ cellularity & mesangial expansion. What’s on your differential? 🧵👇
True vs. Pseudo-Crescents
Differentiating crescents in kidney transplant biopsies:
• True crescents: Breaks in GBM with fibrin deposition.
• Pseudo-crescents: No fibrin, no break in GBM. Fewer inflammatory cells.
Recurrent GN post-transplantoften mirrors the native disease. Here, mesangial IgA/IgG, C3+,C1q–, & EM mesangial deposits fit crescentic IgA-dominant immune complex GN—a known recurrence.Treatment decision: steroid pulse and iptacopan. Hopefully new B-cell targets soon @AlJurdi
1/3. Hair-straightening products containing glyoxylic acid may cause acute kidney injury (AKI)! A recent NEJM article reports cases of calcium oxalate nephropathy linked to these products. Murine models confirm kidney damage after skin exposure. https://www.nejm.org/doi/full/10.1056/NEJMc2400528
3/3: ⚠️Glyoxylic acid, marketed as a safer alternative to formaldehyde in hair products, may be nephrotoxic. The study suggests discontinuing such products to prevent kidney injury. Public health implications! Thanks @MegSise for presenting it + https://www.sciencedirect.com/science/article/pii/S2468024924017698#:~:text=Hair%2Dstraightening%20procedures%20are%20potential,and%20prevent%20chronic%20kidney%20disease.
One more recent evidence here: https://www.kidney-international.org/article/S0085-2538%2824%2900619-7/fulltext
Obesity affects kidney health, with severe obesity nearly doubling in prevalence over 20 years. Weight loss improves kidney outcomes, but lasting results require lifestyle changes + new tools like anti-obesity meds & surgery. Multidisciplinary care is🔑 #KidneyHealth #Obesity
Great review @JASN_News https://pubmed.ncbi.nlm.nih.gov/39292519/ from @AlpIkizler et al.
Kidney transplants from HIV+ donors to HIV+ recipients. A new study @Dorry_Segev w/ participation @mgh_transplant shows no difference in 3-year survival or graft loss vs. non-HIV donors. Data convincing to move this to routine practice #Transplantation #HIV
Even better news came out today... Historic ruling from the Secretary of the Health and Human Services has determined that clinical research is no longer required for HIV kidney and liver transplantation in the US. ⬆️Equity with supported safety data. 👏👏 https://www.federalregister.gov/documents/2024/11/27/2024-27410/organ-procurement-and-transplantation-implementation-of-the-hiv-organ-policy-equity-hope-act
© 2024 Leo Riella
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