In March 2024, under the leadership of Leonardo V. Riella, MD, PhD, Massachusetts General Hospital performed the world’s first successful kidney transplant from a gene-edited pig into a living human, a historic milestone in the effort to address the global organ shortage. Since then, Dr. Riella’s team has completed three additional porcine kidney transplants, making this the largest series of living human xenotransplants to date. These groundbreaking procedures are part of the first FDA-approved clinical study in kidney xenotransplantation, designed to evaluate safety, immune compatibility, and long-term function. Dr. Riella’s research program continues to drive the science forward—applying multi-omics profiling, CRISPR-based gene editing insights, and precision immunosuppression strategies to improve xenograft survival and inform next-generation protocols.