Nice debate on ASN Transplant Community about the use of IVIG for BK nephropathy. Personally, I have used IVIG in a handful of patients with refractory BK nephropathy in the past.…
Leonardo Riella02/2017
Abstract Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. An isoform of proteasome, the immunoproteasome (i-20S), is highly expressed in human T…
Leonardo Riella01/2017
Abstract The incidence of malignancy is greater in kidney transplant recipients compared to the general population, though the higher risk is not equally distributed to all types of cancers. In…
Leonardo Riella01/2017
Abstract Improving long-term graft survival remains one of the critical challenges facing kidney transplantation since a great portion of kidney grafts are lost by 10years after transplantation. Understanding the causes…
Leonardo Riella12/2016
PURPOSE OF REVIEW: The present review aims to highlight the major recent advances in transplantation with regards to basic, translational, and clinical research. RECENT FINDINGS: We describe new concepts in…
Leonardo Riella09/2016
Regulatory CD4+ Foxp3+ T cells (Tregs) are critical in controlling immunity and tolerance. Thus, preserving Treg numbers and function in transplanted patients is essential for the successful minimization of maintenance…
Leonardo Riella09/2016
Belatacept has been introduced as a promising novel immunosuppressant to the field of transplantation, especially for patients suffering from adverse effects of conventional immunosuppression such as nephrotoxicity. Analysis of rejection…
Leonardo Riella07/2016
The prevalence of Hepatitis C Virus (HCV) infection is significantly higher in patients with end-stage renal disease compared to the general population and poses important clinical challenges in patients who…
Leonardo Riella07/2016
Belatacept and Long-Term Outcomes in Kidney Transplantation. Riella LV, Gabardi S, Azzi J. N Engl J Med. 2016 Jun 30;374(26):2599-600. doi: 10.1056/NEJMc1602859#SA4. To the Editor: We congratulate Dr. Vincenti and…
Leonardo Riella07/2016