Authors: Riella LV, Alegre, Maria-Luisa. The prevailing dogma is that CNI-mediated inhibition of T cell activation is due to the reduced IL-2 production that occurs because of impaired NFAT nuclear translocation, as…
Belatacept in kidney transplantation - past and future perspectives. Authors: Siddiqui Z, Tedesco-Silva H, Riella LV. Abstract Calcineurin inhibitors (CNIs) are used widely for maintenance immunosuppression in renal transplant recipients.…
Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. Authors: Park J, Lin HY, Assaker JP1, Jeong S, Huang CH, Kurdi T1, Lee K, Fraser K, Min C,…
Longitudinal immunological characterization of the first presensitized recipient of a face transplant Abstract Rejection affects greater than 80% of face transplants, yet no diagnostic criteria for antibody mediated rejection (AMR) following…
Acellular Hypothermic Extracorporeal Perfusion Extends Allowable Ischemia Time in a Porcine Whole Limb Replantation Model Abstract Background: One of the major challenges in traumatic amputation is the need to keep…
Abstract Chronic allograft injury (CAI) remains one of the biggest challenges in transplantation as it directly affects long-term allograft survival, an area in which the scientific and transplantation community has…
Abstract Although gene-environment interactions have been investigated for many years to understand people’s susceptibility to autoimmune diseases or cancer, a role for environmental factors in modulating alloimmune responses and transplant…
Abstract Calcineurin inhibitors (CNIs) are used widely for maintenance immunosuppression in renal transplant recipients. However, their side effect profile has led researchers to attempt to find safer alternatives that can…