Publications

Testing for High-Risk APOL1 Alleles in Potential Living Kidney Donors

Accurate risk assessment is critical when evaluating potential living kidney donors. High-risk kidney APOL1 variants have been associated with end-stage renal disease of multiple causes among African Americans, though the predictive power…

Leonardo Riella07/2015

Publications Research Articles

Salt Accelerates Allograft Rejection through Serum- and Glucocorticoid-Regulated Kinase-1-Dependent Inhibition of Regulatory T Cells.

A high-salt diet (HSD) in humans is linked to a number of complications, including hypertension and cardiovascular events. Whether a HSD affects the immune response in transplantation is unknown. Using…

Leonardo Riella04/2015

Publications Reviews

Acute rejection in vascularized composite allotransplantation

PURPOSE OF REVIEW: Acute rejection is the most common complication after vascularized composite allotransplantation (VCA). This review provides a state-of-the-art analysis of prevention, diagnosis and treatment of acute rejection episodes…

Leonardo Riella12/2014

Publications Research Articles

Risk of metabolic complications in kidney transplantation after conversion to mTOR inhibitor: a systematic review and meta-analysis.

Mammalian target of rapamycin (mTOR) inhibitors have been used in transplantation with the hope of minimizing calcineurin inhibitor (CNI)-induced nephrotoxicity. However, mTOR inhibitors are also associated with a range of…

Leonardo Riella10/2014

Editorials/Perspectives Publications

Counseling potential donors to the risk of ESRD after kidney donation: glass half-full or half-empty?

Comment on Risk of end-stage renal disease following live kidney donation. Counseling potential donors to the risk of ESRD after kidney donation: glass half-full or half-empty? Allegretti AS, Yeung MY,…

Leonardo Riella10/2014

Publications Research Articles

Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study.

Rabbit antithymocyte globulin (ATG) is commonly used as an induction therapy in renal transplant recipients, but the ideal dosage in tacrolimus-based early steroid withdrawal protocols has not been established. The…

Leonardo Riella08/2014

Publications Reviews

Co-inhibitory pathways and their importance in immune regulation.

Immune regulation is critical for the maintenance of peripheral self-tolerance and for down-regulation of immune responses. Understanding its mechanisms may permit the development of novel targets for the promotion of…

Leonardo Riella07/2014

Publications Research Articles

Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch.

BACKGROUND: More than 30% of potential kidney transplant recipients have pre-existing anti-human leukocyte antigen antibodies. This subgroup has significantly lower transplant rates and increased mortality. Desensitization has become an important…

Leonardo Riella06/2014

Publications Reviews

Beyond calcineurin inhibitors: emerging agents in kidney transplantation.

PURPOSE OF REVIEW: Despite their effectiveness, calcineurin inhibitors (CNIs) represent a major obstacle in the improvement of long-term graft survival in transplantation. The identification of new agents to implement CNI-free…

Leonardo Riella11/2013

Publications Reviews

T-cell co-stimulatory blockade in transplantation: two steps forward one step back!

INTRODUCTION: The concern about nephrotoxicity with calcineurin inhibitors led to the search of novel agents for immunosuppression. Based on the requirement of T-cell co-stimulatory signals to fully activated naïve T…

Leonardo Riella11/2013

Testing for High-Risk APOL1 Alleles in Potential Living Kidney Donors

Salt Accelerates Allograft Rejection through Serum- and Glucocorticoid-Regulated Kinase-1-Dependent Inhibition of Regulatory T Cells.

Acute rejection in vascularized composite allotransplantation

Risk of metabolic complications in kidney transplantation after conversion to mTOR inhibitor: a systematic review and meta-analysis.

Counseling potential donors to the risk of ESRD after kidney donation: glass half-full or half-empty?

Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study.

Co-inhibitory pathways and their importance in immune regulation.

Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch.

Beyond calcineurin inhibitors: emerging agents in kidney transplantation.

T-cell co-stimulatory blockade in transplantation: two steps forward one step back!

Congrats to TANGO group, especially Frank Hullekes and Ruchama Verhoeff, in leading our publications from the TANGO study on recurrence of glomerular disease

Congrats to Rodrigo Gassen for his publication on the impact of ATG on follicular helper cells AJT

Congrats to Orhan Efe, Rodrigo Gassen, Thiago Borges and Ayman Al Jurdi for getting grants funded!

Upcoming Talk Nov 8th 2023: Houston Methodist

Upcoming Talk May 2024: NKF 2024 Spring Clinical Meeting, Long Beach, CA

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