Human regulatory T cells undergo self-inflicted damage via granzyme pathways upon activation. Authors: Sula Karreci E1, Eskandari SK1, Dotiwala F2, Routray SK1, Kurdi AT3, Assaker JP1, Luckyanchykov P1, Mihali AB1,…
Leonardo Riella08/2018
Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. Authors: Park J, Lin HY, Assaker JP1, Jeong S, Huang CH, Kurdi T1, Lee K, Fraser K, Min C,…
Leonardo Riella08/2018
Longitudinal immunological characterization of the first presensitized recipient of a face transplant Abstract Rejection affects greater than 80% of face transplants, yet no diagnostic criteria for antibody mediated rejection (AMR) following…
Leonardo Riella10/2017
Acellular Hypothermic Extracorporeal Perfusion Extends Allowable Ischemia Time in a Porcine Whole Limb Replantation Model Abstract Background: One of the major challenges in traumatic amputation is the need to keep…
Leonardo Riella07/2017
Abstract Chronic allograft injury (CAI) remains one of the biggest challenges in transplantation as it directly affects long-term allograft survival, an area in which the scientific and transplantation community has…
Leonardo Riella07/2017
Abstract Although gene-environment interactions have been investigated for many years to understand people’s susceptibility to autoimmune diseases or cancer, a role for environmental factors in modulating alloimmune responses and transplant…
Leonardo Riella07/2017
Abstract Calcineurin inhibitors (CNIs) are used widely for maintenance immunosuppression in renal transplant recipients. However, their side effect profile has led researchers to attempt to find safer alternatives that can…
Leonardo Riella07/2017
Authors Rimda Wanchoo, Leonardo V. Riella, Nupur N. Uppal, Carlos A. Lopez, Vinay Nair, Craig Devoe, Kenar D. Jhaveri Abstract The use of immune checkpoint inhibitors (ICI) in several cancers is expanding; however, their use in patients with cancer and an organ transplant…
Leonardo Riella01/2017
Abstract Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. An isoform of proteasome, the immunoproteasome (i-20S), is highly expressed in human T…
Leonardo Riella01/2017