Immune rejection is mediated by a complex interplay of cellular and humoral mechanisms. Current therapeutic strategies, which rely on global immunosuppression, can result in serious complications and are not completely…
Leonardo Riella04/2016
Riella LV, Chandraker A. “Transplant-related Complications,” In: Li and Jevnikar. "AST Handbook of Transplant Immunology". 1st Edition, Wiley Blackwell 2015
Leonardo Riella03/2016
Riella LV, Riella MC. “Global Considerations of Kidney Disease – Latin America,” In: Brenner & Rector’s “The Kidney”. 9ht Edition, Saunders 2015; Chapter 77, Pages 2440-2452.
Leonardo Riella03/2016
Chandraker A, Riella LV, Sayegh MH. “Transplantation Immunobiology,” In: Brenner & Rector’s “The Kidney”. 9ht Edition, ; Saunders 2015; Chapter 71, Pages 2228-2250
Leonardo Riella03/2016
Facial transplantation is a life-changing procedure for patients with severe composite facial defects. However, skin is the most immunogenic of all transplants and better understanding of the immunological processes after…
Leonardo Riella01/2016
The Notch signaling pathway is known to play a pivotal role in T- and B-cell development and fate, presenting it as an attractive therapeutic target in alloimmunity. This review provides…
Leonardo Riella01/2016
CD28 is a well-characterized co-stimulatory molecule that interacts with CD80/86 on antigen-presenting cells (APCs), comprising the critical signal 2 of T cell activation. Targeting CD28 has become an important immunosuppressive…
Leonardo Riella01/2016
Accurate risk assessment is critical when evaluating potential living kidney donors. High-risk kidney APOL1 variants have been associated with end-stage renal disease of multiple causes among African Americans, though the predictive power…
Leonardo Riella07/2015
A high-salt diet (HSD) in humans is linked to a number of complications, including hypertension and cardiovascular events. Whether a HSD affects the immune response in transplantation is unknown. Using…
Leonardo Riella04/2015