Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. Authors: Park J, Lin HY, Assaker JP1, Jeong S, Huang CH, Kurdi T1, Lee K, Fraser K, Min C,…
Leonardo Riella08/2018
Acellular Hypothermic Extracorporeal Perfusion Extends Allowable Ischemia Time in a Porcine Whole Limb Replantation Model Abstract Background: One of the major challenges in traumatic amputation is the need to keep…
Leonardo Riella07/2017
Abstract Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. An isoform of proteasome, the immunoproteasome (i-20S), is highly expressed in human T…
Leonardo Riella01/2017
Belatacept has been introduced as a promising novel immunosuppressant to the field of transplantation, especially for patients suffering from adverse effects of conventional immunosuppression such as nephrotoxicity. Analysis of rejection…
Leonardo Riella07/2016
The prevalence of Hepatitis C Virus (HCV) infection is significantly higher in patients with end-stage renal disease compared to the general population and poses important clinical challenges in patients who…
Leonardo Riella07/2016
Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis,…
Leonardo Riella07/2016
B cells play a central role in antibody-mediated rejection and certain auto-immune diseases. However, B-cell-targeted therapy such as anti-CD20 B cell-depleting antibody(aCD20) has yielded mixed results in improving outcomes. In…
Leonardo Riella06/2016
Facial transplantation is a life-changing procedure for patients with severe composite facial defects. However, skin is the most immunogenic of all transplants and better understanding of the immunological processes after…
Leonardo Riella01/2016
A high-salt diet (HSD) in humans is linked to a number of complications, including hypertension and cardiovascular events. Whether a HSD affects the immune response in transplantation is unknown. Using…
Leonardo Riella04/2015