Publications

Publications Research Articles

Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice.

Abstract Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. An isoform of proteasome, the immunoproteasome (i-20S), is highly expressed in human T…

Leonardo Riella01/2017

Publications Reviews

Acute myeloid leukemia after kidney transplantation: a case report and literature review.

Abstract The incidence of malignancy is greater in kidney transplant recipients compared to the general population, though the higher risk is not equally distributed to all types of cancers. In…

Leonardo Riella01/2017

Publications Reviews

Chronic allograft injury: Mechanisms and potential treatment targets.

Abstract Improving long-term graft survival remains one of the critical challenges facing kidney transplantation since a great portion of kidney grafts are lost by 10years after transplantation. Understanding the causes…

Leonardo Riella12/2016

Publications Reviews

Current status of alloimmunity.

PURPOSE OF REVIEW: The present review aims to highlight the major recent advances in transplantation with regards to basic, translational, and clinical research. RECENT FINDINGS: We describe new concepts in…

Leonardo Riella09/2016

Publications Reviews

Treg-Centric View of Immunosuppressive Drugs in Transplantation: A Balancing Act.

Regulatory CD4+ Foxp3+ T cells (Tregs) are critical in controlling immunity and tolerance. Thus, preserving Treg numbers and function in transplanted patients is essential for the successful minimization of maintenance…

Leonardo Riella09/2016

Publications Research Articles

Immunological characteristics of a patient with Belatacept-resistant acute rejection after face transplantation.

Belatacept has been introduced as a promising novel immunosuppressant to the field of transplantation, especially for patients suffering from adverse effects of conventional immunosuppression such as nephrotoxicity. Analysis of rejection…

Leonardo Riella07/2016

Research Articles

Efficacy and Safety of Direct Acting Antivirals in Kidney Transplant Recipients with Chronic Hepatitis C Virus Infection

The prevalence of Hepatitis C Virus (HCV) infection is significantly higher in patients with end-stage renal disease compared to the general population and poses important clinical challenges in patients who…

Leonardo Riella07/2016

Editorials/Perspectives

Belatacept and Long-Term Outcomes in Kidney Transplantation

Belatacept and Long-Term Outcomes in Kidney Transplantation. Riella LV, Gabardi S, Azzi J. N Engl J Med. 2016 Jun 30;374(26):2599-600. doi: 10.1056/NEJMc1602859#SA4. To the Editor: We congratulate Dr. Vincenti and…

Leonardo Riella07/2016

Editorials/Perspectives

Coronary artery calcium density for the prediction of mortality in CKD patients: One size does not fit all

The coronary artery calcium (CAC) score is a widely recognized surrogate marker of coronary atherosclerosis, and its presence and extent are associated with increased risk of incident cardiovascular events and…

Leonardo Riella07/2016

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