The coronary artery calcium (CAC) score is a widely recognized surrogate marker of coronary atherosclerosis, and its presence and extent are associated with increased risk of incident cardiovascular events and…
Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis,…
B cells play a central role in antibody-mediated rejection and certain auto-immune diseases. However, B-cell-targeted therapy such as anti-CD20 B cell-depleting antibody(aCD20) has yielded mixed results in improving outcomes. In…
Immune rejection is mediated by a complex interplay of cellular and humoral mechanisms. Current therapeutic strategies, which rely on global immunosuppression, can result in serious complications and are not completely…
Digital Learning in Transplantation. Riella LV. Transplantation. 2016 Apr;100(4):701-702. PMID: 26998849 Physicians are lifetime learners in a world of rapidly changing information. Understanding the science of learning well and using the best available tools…
Riella LV, Chandraker A. “Transplant-related Complications,” In: Li and Jevnikar. "AST Handbook of Transplant Immunology". 1st Edition, Wiley Blackwell 2015
The immune system has to be tightly regulated to avoid collateral damage. The discovery of regulatory cells in 1985 yielded one of the most important immunological advances in the past…