Publications

Research Articles

Severe acute interstitial nephritis after combination immune-checkpoint inhibitor therapy for metastatic melanoma

Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis,…

Leonardo Riella07/2016

Publications Research Articles

Inflammation causes resistance to anti-CD20 mediated B cell depletion

B cells play a central role in antibody-mediated rejection and certain auto-immune diseases. However, B-cell-targeted therapy such as anti-CD20 B cell-depleting antibody(aCD20) has yielded mixed results in improving outcomes. In…

Leonardo Riella06/2016

Publications Reviews

Targeting the Notch pathway to prevent rejection.

Immune rejection is mediated by a complex interplay of cellular and humoral mechanisms. Current therapeutic strategies, which rely on global immunosuppression, can result in serious complications and are not completely…

Leonardo Riella04/2016

Editorials/Perspectives Publications

Digital Learning in Transplantation

Digital Learning in Transplantation. Riella LV. Transplantation. 2016 Apr;100(4):701-702. PMID: 26998849 Physicians are lifetime learners in a world of rapidly changing information. Understanding the science of learning well and using the best available tools…

Leonardo Riella03/2016

Book Chapters Publications

Transplant-Related Complications

Riella LV, Chandraker A. “Transplant-related Complications,” In: Li and Jevnikar. "AST Handbook of Transplant Immunology". 1st Edition, Wiley Blackwell 2015

Leonardo Riella03/2016

Book Chapters Publications

Global Considerations of Kidney Disease – Latin America

Riella LV, Riella MC. “Global Considerations of Kidney Disease – Latin America,” In: Brenner & Rector’s “The Kidney”. 9ht Edition, Saunders 2015; Chapter 77, Pages 2440-2452.

Leonardo Riella03/2016

Book Chapters Publications

Transplantation Immunobiology

Chandraker A, Riella LV, Sayegh MH. “Transplantation Immunobiology,” In: Brenner & Rector’s “The Kidney”. 9ht Edition, ; Saunders 2015; Chapter 71, Pages 2228-2250

Leonardo Riella03/2016

Blog Immune regulation

NephMadness 2016: The Promising Future of Tregs in Transplantation

The immune system has to be tightly regulated to avoid collateral damage. The discovery of regulatory cells in 1985 yielded one of the most important immunological advances in the past…

Leonardo Riella03/2016

Publications Research Articles

Co-Dominant Role of IFN-γ- and IL-17-Producing T Cells During Rejection in Full Facial Transplant Recipients.

Facial transplantation is a life-changing procedure for patients with severe composite facial defects. However, skin is the most immunogenic of all transplants and better understanding of the immunological processes after…

Leonardo Riella01/2016

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