One controversial aspect in the evaluation of potential kidney recipients is the performance of stress tests for risk stratification. With the cost of stress tests ranging from U$2,500-5,000 and the long waiting…
Leonardo Riella09/2015
Accurate risk assessment is critical when evaluating potential living kidney donors. High-risk kidney APOL1 variants have been associated with end-stage renal disease of multiple causes among African Americans, though the predictive power…
Leonardo Riella07/2015
Membranoproliferative glomerulonephritis on kidney biopsy. Monoclonal gammopathies generally arise from the development of an abnormal clone of B-cell lineage. The monoclonal protein can be intact immunoglogulin (often associated with free…
Leonardo Riella06/2015
What are the most common type of cancers in kidney transplant recipients? Post-transplant malignancy The four most common cancers are: non-melanoma skin cancers, Kaposi’s sarcoma, kidney cancer and non-Hodgkin lymphomas. Compared…
Leonardo Riella04/2015
Prior HBV infection is not a contraindication to kidney transplantation. Hepatitis B Virus It is critical to evaluate patients with serologies and HBV DNA viral load prior to transplant. Most patients…
Leonardo Riella04/2015
Pregnancy after Kidney Transplantation While end-stage kidney disease is associated with a high rate of infertility likely related to hormonal changes and anovulation, patients undergoing renal transplantation resume menstrual cycles…
Leonardo Riella04/2015
A high-salt diet (HSD) in humans is linked to a number of complications, including hypertension and cardiovascular events. Whether a HSD affects the immune response in transplantation is unknown. Using…
Leonardo Riella04/2015
Protein Structure All HLA antigens are composed of strings of several polymorphic sites, which may serve as targets, or epitopes, for antibody binding. An important consideration is that HLA antigens…
Leonardo Riella03/2015