Publications

Blog Medical Complications Post-Transplant

Pregnancy after Kidney Transplantation – Hope with Caution…

Pregnancy after Kidney Transplantation While end-stage kidney disease is associated with a high rate of infertility likely related to hormonal changes and anovulation, patients undergoing renal transplantation resume menstrual cycles…

Leonardo Riella04/2015

Publications Research Articles

Salt Accelerates Allograft Rejection through Serum- and Glucocorticoid-Regulated Kinase-1-Dependent Inhibition of Regulatory T Cells.

A high-salt diet (HSD) in humans is linked to a number of complications, including hypertension and cardiovascular events. Whether a HSD affects the immune response in transplantation is unknown. Using…

Leonardo Riella04/2015

Blog Histocompatibility

Is Matching at the HLA Epitope Level the Holy Grail of Longer Graft Survival?

Protein Structure All HLA antigens are composed of strings of several polymorphic sites, which may serve as targets, or epitopes, for antibody binding. An important consideration is that HLA antigens…

Leonardo Riella03/2015

Publications Reviews

Acute rejection in vascularized composite allotransplantation

PURPOSE OF REVIEW: Acute rejection is the most common complication after vascularized composite allotransplantation (VCA). This review provides a state-of-the-art analysis of prevention, diagnosis and treatment of acute rejection episodes…

Leonardo Riella12/2014

Publications Research Articles

Risk of metabolic complications in kidney transplantation after conversion to mTOR inhibitor: a systematic review and meta-analysis.

Mammalian target of rapamycin (mTOR) inhibitors have been used in transplantation with the hope of minimizing calcineurin inhibitor (CNI)-induced nephrotoxicity. However, mTOR inhibitors are also associated with a range of…

Leonardo Riella10/2014

Editorials/Perspectives Publications

Counseling potential donors to the risk of ESRD after kidney donation: glass half-full or half-empty?

Comment on Risk of end-stage renal disease following live kidney donation. Counseling potential donors to the risk of ESRD after kidney donation: glass half-full or half-empty? Allegretti AS, Yeung MY,…

Leonardo Riella10/2014

Publications Research Articles

Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study.

Rabbit antithymocyte globulin (ATG) is commonly used as an induction therapy in renal transplant recipients, but the ideal dosage in tacrolimus-based early steroid withdrawal protocols has not been established. The…

Leonardo Riella08/2014

Publications Reviews

Co-inhibitory pathways and their importance in immune regulation.

Immune regulation is critical for the maintenance of peripheral self-tolerance and for down-regulation of immune responses. Understanding its mechanisms may permit the development of novel targets for the promotion of…

Leonardo Riella07/2014

Publications Research Articles

Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch.

BACKGROUND: More than 30% of potential kidney transplant recipients have pre-existing anti-human leukocyte antigen antibodies. This subgroup has significantly lower transplant rates and increased mortality. Desensitization has become an important…

Leonardo Riella06/2014

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