INTRODUCTION: The concern about nephrotoxicity with calcineurin inhibitors led to the search of novel agents for immunosuppression. Based on the requirement of T-cell co-stimulatory signals to fully activated naïve T…
Regulatory T cells (Tregs) play a pivotal role in the maintenance of immune tolerance and hold great promise as cell therapy for a variety of immune-mediated diseases. However, the cellular…
The Notch pathway is an important intercellular signaling pathway that plays a major role in controlling cell fate. Accumulating evidence indicates that Notch and its ligands present on antigen-presenting cells…
In a successful pregnancy, the semiallogeneic fetus is not rejected by the maternal immune system, which implies tolerance mechanisms protecting fetal tissues from maternal immune attack. Here we report that…
Fever, dysuria and elevated serum creatinine in a kidney transplant recipient. Batal I, Bijol V, Riella LV, Rennke HG. Am J Transplant. 2013 Mar;13(3):817-8.
Riella LV, Chandraker A “Living donation – The gold standard,” In: Kandaswamy and Mamode Abdominal Transplantation; the State of the Art. 1st Edition, Blackwell 2013, 1st Edition; Pages 9-24.
Understanding immunoregulatory mechanisms is essential for the development of novel interventions to improve long-term allograft survival. Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, have emerged as critical…