Publications

Publications Reviews

Acute rejection in vascularized composite allotransplantation

PURPOSE OF REVIEW: Acute rejection is the most common complication after vascularized composite allotransplantation (VCA). This review provides a state-of-the-art analysis of prevention, diagnosis and treatment of acute rejection episodes…

Leonardo Riella12/2014

Publications Research Articles

Risk of metabolic complications in kidney transplantation after conversion to mTOR inhibitor: a systematic review and meta-analysis.

Mammalian target of rapamycin (mTOR) inhibitors have been used in transplantation with the hope of minimizing calcineurin inhibitor (CNI)-induced nephrotoxicity. However, mTOR inhibitors are also associated with a range of…

Leonardo Riella10/2014

Editorials/Perspectives Publications

Counseling potential donors to the risk of ESRD after kidney donation: glass half-full or half-empty?

Comment on Risk of end-stage renal disease following live kidney donation. Counseling potential donors to the risk of ESRD after kidney donation: glass half-full or half-empty? Allegretti AS, Yeung MY,…

Leonardo Riella10/2014

Publications Research Articles

Immunophenotyping and efficacy of low dose ATG in non-sensitized kidney recipients undergoing early steroid withdrawal: a randomized pilot study.

Rabbit antithymocyte globulin (ATG) is commonly used as an induction therapy in renal transplant recipients, but the ideal dosage in tacrolimus-based early steroid withdrawal protocols has not been established. The…

Leonardo Riella08/2014

Publications Reviews

Co-inhibitory pathways and their importance in immune regulation.

Immune regulation is critical for the maintenance of peripheral self-tolerance and for down-regulation of immune responses. Understanding its mechanisms may permit the development of novel targets for the promotion of…

Leonardo Riella07/2014

Publications Research Articles

Long-term outcomes of kidney transplantation across a positive complement-dependent cytotoxicity crossmatch.

BACKGROUND: More than 30% of potential kidney transplant recipients have pre-existing anti-human leukocyte antigen antibodies. This subgroup has significantly lower transplant rates and increased mortality. Desensitization has become an important…

Leonardo Riella06/2014

Publications Reviews

Beyond calcineurin inhibitors: emerging agents in kidney transplantation.

PURPOSE OF REVIEW: Despite their effectiveness, calcineurin inhibitors (CNIs) represent a major obstacle in the improvement of long-term graft survival in transplantation. The identification of new agents to implement CNI-free…

Leonardo Riella11/2013

Publications Reviews

T-cell co-stimulatory blockade in transplantation: two steps forward one step back!

INTRODUCTION: The concern about nephrotoxicity with calcineurin inhibitors led to the search of novel agents for immunosuppression. Based on the requirement of T-cell co-stimulatory signals to fully activated naïve T…

Leonardo Riella11/2013

Publications Research Articles

Serine protease inhibitor 6 plays a critical role in protecting murine granzyme B-producing regulatory T cells.

Regulatory T cells (Tregs) play a pivotal role in the maintenance of immune tolerance and hold great promise as cell therapy for a variety of immune-mediated diseases. However, the cellular…

Leonardo Riella09/2013

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