Successful Treatment of Posttransplant Monoclonal Gammopathy-associated C3 Glomerulopathy

C3 glomerulonephritis (C3GN) results from activation of the alternative complement pathway (ACP) frequently because of genetic mutations or autoantibodies targeting regulators of the pathway.1 C3GN recurrence after kidney transplant is common and is associated with a high risk of allograft loss.2,3 Limited data exist on the treatment of C3GN after kidney transplantation.3,4 In this case report, we highlight a case of early C3GN after living unrelated kidney transplantation associated with an IgG λ monoclo- nal gammopathy that was treated successfully with plasma cell clone-directed therapy.