Abstract Improving long-term graft survival remains one of the critical challenges facing kidney transplantation since a great portion of kidney grafts are lost by 10years after transplantation. Understanding the causes…
Leonardo Riella12/2016
Regulatory CD4+ Foxp3+ T cells (Tregs) are critical in controlling immunity and tolerance. Thus, preserving Treg numbers and function in transplanted patients is essential for the successful minimization of maintenance…
Leonardo Riella09/2016
Belatacept has been introduced as a promising novel immunosuppressant to the field of transplantation, especially for patients suffering from adverse effects of conventional immunosuppression such as nephrotoxicity. Analysis of rejection…
Leonardo Riella07/2016
The prevalence of Hepatitis C Virus (HCV) infection is significantly higher in patients with end-stage renal disease compared to the general population and poses important clinical challenges in patients who…
Leonardo Riella07/2016
Belatacept and Long-Term Outcomes in Kidney Transplantation. Riella LV, Gabardi S, Azzi J. N Engl J Med. 2016 Jun 30;374(26):2599-600. doi: 10.1056/NEJMc1602859#SA4. To the Editor: We congratulate Dr. Vincenti and…
Leonardo Riella07/2016
The coronary artery calcium (CAC) score is a widely recognized surrogate marker of coronary atherosclerosis, and its presence and extent are associated with increased risk of incident cardiovascular events and…
Leonardo Riella07/2016
Immune-checkpoint inhibitors are emerging as revolutionary drugs for certain malignancies. However, blocking the co-inhibitory signals may lead to immune-related adverse events, mainly in the spectrum of autoimmune diseases including colitis,…
Leonardo Riella07/2016
B cells play a central role in antibody-mediated rejection and certain auto-immune diseases. However, B-cell-targeted therapy such as anti-CD20 B cell-depleting antibody(aCD20) has yielded mixed results in improving outcomes. In…
Leonardo Riella06/2016
Immune rejection is mediated by a complex interplay of cellular and humoral mechanisms. Current therapeutic strategies, which rely on global immunosuppression, can result in serious complications and are not completely…
Leonardo Riella04/2016