Chandraker A, Riella LV, Sayegh MH. “Transplantation Immunobiology,” In: Brenner & Rector’s “The Kidney”. 9ht Edition, ; Saunders 2015; Chapter 71, Pages 2228-2250
Leonardo Riella03/2016
Facial transplantation is a life-changing procedure for patients with severe composite facial defects. However, skin is the most immunogenic of all transplants and better understanding of the immunological processes after…
Leonardo Riella01/2016
The Notch signaling pathway is known to play a pivotal role in T- and B-cell development and fate, presenting it as an attractive therapeutic target in alloimmunity. This review provides…
Leonardo Riella01/2016
CD28 is a well-characterized co-stimulatory molecule that interacts with CD80/86 on antigen-presenting cells (APCs), comprising the critical signal 2 of T cell activation. Targeting CD28 has become an important immunosuppressive…
Leonardo Riella01/2016
For severe or refractory rejections, thymoglobulin/ATG is commonly employed in combination with steroids and B-cell targeted therapies when indicated. However, alemtuzumab could be more effective then thymoglobulin since it depletes…
Leonardo Riella09/2015
One controversial aspect in the evaluation of potential kidney recipients is the performance of stress tests for risk stratification. With the cost of stress tests ranging from U$2,500-5,000 and the long waiting…
Leonardo Riella09/2015
A 31 year-old healthy male donated his kidney to his mother who had IgA nephropathy. Prior to donation, his creatinine was 1.08 mg/dl. One year after donation, his creatinine is…
Leonardo Riella08/2015